Detailed view for EgrG_900000300

Basic information

TDR Targets ID: 575450
Echinococcus granulosus, NADH dehydrogenase subunit 4
Source Database / ID:  GeneDB

pI: 5.8742 | Length (AA): 404 | MW (Da): 46038 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 11

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00361   Proton-conducting membrane transporter

Gene Ontology

Mouse over links to read term descriptions.
GO:0008137   NADH dehydrogenase (ubiquinone) activity  
GO:0042773   ATP synthesis coupled electron transport  
GO:0055114   oxidation reduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129156)

Species Accession Gene Product
Arabidopsis thaliana ArthMp051   NADH dehydrogenase subunit 4
Arabidopsis thaliana ArthCp074   NADH dehydrogenase subunit 4
Candida albicans CaalfMp14   NADH dehydrogenase subunit 4
Dictyostelium discoideum DidioMp02   NADH dehydrogenase subunit 4
Escherichia coli b2277   NADH:ubiquinone oxidoreductase, membrane subunit M
Echinococcus granulosus EgrG_900000300   NADH dehydrogenase subunit 4
Homo sapiens 4538   NADH dehydrogenase, subunit 4 (complex I)
Mus musculus 17719   NADH dehydrogenase subunit 4
Mycobacterium tuberculosis Rv3157   Probable NADH dehydrogenase I (chain M) NUOK (NADH-ubiquinone oxidoreductase chain M)
Mycobacterium ulcerans MUL_2471   NADH dehydrogenase subunit M
Oryza sativa 9271662   Os12g0525100
Oryza sativa 6450121   NADH dehydrogenase subunit 4
Oryza sativa 3131398   NADH dehydrogenase subunit 4
Wolbachia endosymbiont of Brugia malayi Wbm0622   NADH:ubiquinone oxidoreductase chain M

Essentiality

EgrG_900000300 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b2277 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens NADH dehydrogenase, subunit 4 (complex I) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0246 0.2647 0.291
0.0305 0.9712 0.9703
0.0366 0.437 0.4364
0.0305 0.9712 0.9703
0.0305 0.9712 0.9703

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_900000300 (Echinococcus granulosus), NADH dehydrogenase subunit 4
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